Weekend Edition!

An age clock. A dramatic reversal. Moon Unit Zappa.

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1. An age ‘clock’ based on some 200 proteins found in the blood can predict a person’s risk of developing 18 chronic illnesses, including heart disease, cancer, diabetes and Alzheimer’s disease. The clock’s accuracy raises the prospect of developing a single test that could describe a person’s risk of many chronic conditions, says the project’s lead scientist Austin Argentieri, a population-health researcher at Massachusetts General Hospital in Boston. “Ultimately, wanting to live longer will come down to preventing chronic diseases,” he says. The study was published in Nature Medicine on 8 August. (Source: nature.com)

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2. Long COVID science, research and policy:

Long COVID represents the constellation of post-acute and long-term health effects caused by SARS-CoV-2 infection; it is a complex, multisystem disorder that can affect nearly every organ system and can be severely disabling. The cumulative global incidence of long COVID is around 400 million individuals, which is estimated to have an annual economic impact of approximately $1 trillion—equivalent to about 1% of the global economy. Several mechanistic pathways are implicated in long COVID, including viral persistence, immune dysregulation, mitochondrial dysfunction, complement dysregulation, endothelial inflammation and microbiome dysbiosis. Long COVID can have devastating impacts on individual lives and, due to its complexity and prevalence, it also has major ramifications for health systems and economies, even threatening progress toward achieving the Sustainable Development Goals. Addressing the challenge of long COVID requires an ambitious and coordinated—but so far absent—global research and policy response strategy. In this interdisciplinary review, we provide a synthesis of the state of scientific evidence on long COVID, assess the impacts of long COVID on human health, health systems, the economy and global health metrics, and provide a forward-looking research and policy roadmap. (Source: nature.com, nytimes.com)

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3. Vice President Kamala Harris leads former President Donald J. Trump in three crucial battleground states, according to new surveys by The New York Times and Siena College, the latest indication of a dramatic reversal in standing for Democrats after President Biden’s departure from the presidential race remade it. Ms. Harris is ahead of Mr. Trump by four percentage points in Wisconsin, Pennsylvania and Michigan, 50 percent to 46 percent among likely voters in each state. The surveys were conducted from Aug. 5 to 9. The polls, some of the first high-quality surveys in those states since Mr. Biden announced he would no longer run for re-election, come after nearly a year of surveys that showed either a tied contest or a slight lead for Mr. Trump over Mr. Biden. (Source: nytimes.com)